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Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP et al

Recently, growth factors and recombinant proteins such as platelet-derived growth factor (PDGF) and galectin-1 have been used as efficient therapeutics to promote wound healing through ROS modulation

Consistent with these findings, glial cells express more endogenous TDP-43 after treatment with lipopolysaccharide (LPS) or ROS, and produce more pro-inflammatory cytokines and neurotoxic mediators (Swarup et al., 2011)