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The clinical implication of the restart pattern is significant: if the majority of patients who stop GLP-1s eventually come back, then designing treatment programs around episodic short-term use rather than chronic long-term management may be setting patients up for the regain-and-restart cycle documented in this data

Some studies have shown that the less PGE 2 production might contribute to the lower level of fungal virulence (Ells et al., 2 is sorely needed

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