There was no evidence demonstrating other significant safety issue differences (e.g., serious AEs) between GLP-1RA plus SGLT2i combination therapy and either GLP-1RA or SGLT2i monotherapy [59]
Jensen MH, Kjolby M, Hejlesen O, et al
For severe symptoms, call 911 or go to the nearest emergency room
This allows a licensed provider to look at your health profile and discuss any pre-existing conditionslike heart issues or severe acid refluxthat might affect your experience with semaglutide or tirzepatide
On one hand, IBD can lead to dysregulation of adipokines, shifting the balance towards a pro-inflammatory state, on the other hand obesity and higher BMI are associated with higher risk of developing IBD and worse clinical outcomes, particularly for UC