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DPP4i lower glucose in part through activation of the GLP-1R in mice and humans (1113)

In UM microenvironment, PKC and Ras protein activator RasGRPs together activate MAPK signal, which is an important mechanism of inducing tumor cell growth

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This review examines dysregulation of the KP in MDD, emphasizing KP metabolites particularly quinolinic acid and kynurenic acid as biomarkers and mediators of excitotoxicity, neuroinflammation, and oxidative stress, and discusses the therapeutic efficacy of antidepressants that modulate this pathway