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The medications approval by the US Food and Drug Administration (FDA) underscores its efficacy and safety in addressing weight-related concerns for adults with obesity or overweight and obese adolescents aged 12 and older

All members of the NLR family possess three conserved structural domains that determine their functional mechanisms: (1) The Nterminal effector domain (e.g., CARD, PYD, or BIR domains) mediates interactions with adaptor proteins and downstream signaling effectors, acting as the primary transducer of receptor activation signals

PMID: 39996356