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The phase 3 TRIUMPH-4 trial confirmed these findings

Eur J Pharmacol 12(2):145155 Cubells J, Kranzler H, McCance-Katz E, Anderson G, Malison R, Price L, Gelernter J (2000) A haplotype at the DBH locus, associated with low plasma dopamine -hydroxylase activity, also associates with cocaine-induced paranoia

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Autonomic neuropathy, particularly in ATTRv amyloidosis, disrupts the enteric plexus, leading to loss of inhibitory mechanisms and upregulation of excitatory neurons and subsequently dysmotility symptoms [12, 13]

[PubMed] [Google Scholar] 7.Xu J, Brennan TJ