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Additional Growth Factors Modulated EGF (Epidermal): Promotes epithelial cell proliferation and wound re-epithelialization FGF (Fibroblast): Stimulates fibroblast activity and extracellular matrix production TGF- (Transforming): Regulates scarring and tissue remodeling NGF (Nerve): May contribute to BPC-157's neuroprotective effects Growth Factor Coordination These growth factors work synergistically: VEGF brings blood supply (oxygen, nutrients, repair cells) EGF regenerates epithelial surfaces FGF stimulates connective tissue repair TGF- orchestrates the remodeling phase Receptor Interactions BPC-157's mechanism may involve growth factor receptor modulation, though the exact receptors remain under investigation

Acknowledgements This work was supported by the National Natural Science Foundation of China (grant no 81500354), Beijing Municipal Natural Science Foundation (grant no Z13110200400000) and Wu Jieping Medical Foundation (grant no 320.6750.14331)

Starting at a higher dose dramatically increases the risk and severity of gastrointestinal side effects

Adults usually get 0.5 to 1 mL (500 to 1,000 mcg) weekly