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Many bacteriostatic water vials even carry a warning: Not for use in neonates. Route of Injection: If a medication is going to be injected into the spinal canal or the brain (intrathecal/intraventricular routes) , or in the eye (intraocular) , or sometimes for epidural injections , the use of preservative-free diluents is required

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Notably, NDBs disrupt bacterial membranes instead of targeting specific metabolic pathways, a mechanism less prone to resistance development (Bustamante-Torres et al., 2022