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By preserving NAD+ and SAM in both fat and muscle tissue, NNMT inhibition may theoretically address the metabolic dysfunction underlying both excessive fat storage and impaired muscle maintenance

Published thermodynamic stability studies have characterised the peptide's behaviour across a wide pH range

And in children with autism, glutamate can also be a problematic excitotoxin, which may also be at least one reason why sulforaphane is showing so much promise in this population

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However, there appears to be other more immediate indications for the clinical drug development of Compound 21, such as heart failure, nephroprotection, stroke and anti-inflammation