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Although this phenomenon is considered the primary pathway of melanocyte destruction in vitiligo, the presence of melanocyte-specific T cells is not sufficient, as they have also been found in healthy individuals, showing an anergic phenotype.19,20 Regulatory T cells The imbalance between pro- and anti-inflammatory signaling is crucial in the pathogenesis of vitiligo

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Actually, a number of studies have also shown a metabolic advantage associated with the anti-inflammatory effects of PPAR- targeting (Hevener et al