In humans, HDAC activity was reduced in blood cells following ingestion of 68 g (one cup) of sulforaphane-rich broccoli sprouts (44)
Because the release stays pulse-like rather than a constant flood, the body's own feedback loops are largely preserved, which is part of why this combo is considered a more physiologic approach than synthetic HGH
Importantly, the underlying cell death mechanism is triggered by CBS inhibition in HepG2 cells via ferroptosis, suggesting that CBS has a previously unreported function in this process
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