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By enhancing insulin sensitivity and glucose uptake, berberine can help reduce blood sugar spikes and potentially support weight loss, and may promote longevity

The discontinuation rates due to side effects in late-stage trials on Wegovy and Eli Lilly's weekly obesity injection Zepbound are around 7% or less

Near-maximal, approximately 75% reductions were associated with approximately 20% reductions in body weight

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(54) found that in a letrozole-induced PCOS model, Irpex lacteus polysaccharides reduced insulin levels by enhancing antioxidant enzyme expression, thereby regulating glucose and lipid metabolism