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For example, women who have bariatric surgery frequently have minimal impact on their legs, despite weight loss elsewhere

3 Additional studies are needed to assess the benefits and potential risks of using GLP-1 RAs in HS treatment in patients with and without comorbidities to determine whether GLP-1 RAs should be included in a standardized regimen

In tirzepatide users, the researchers reported that a missense variant in GIPR, rs1800437, increased the risk of vomiting, and estimated that people homozygous for risk alleles at both GLP1R and GIPR had a 14.8fold higher odds of tirzepatiderelated vomiting than those without risk alleles

Glucagon-like peptide-1 receptor agonists (semaglutide and tirzepatide) are a class of medications approved by the U.S