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By treating the complex factors contributing to excess weight, it becomes possible to not only achieve weight loss but sustain it long-term

Initial investigations may include urine culture where infection is suspected and consideration of renal function tests (eGFR, U&Es) if dehydration or acute kidney injury is a concern

They help manage mealtime surges in blood sugar, and then help manage blood sugar between meals or at night

Evening administration before bed makes this fasting window easy to achieve for most schedules

Interestingly, early-stage Alzheimer patients sometimes show elevated serum BDNF, likely as a compensatory mechanism