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The evidence from phase 2 obesity and diabetes trials suggests that it does, although the magnitude and time course of the effect is becoming clearer as more data are published

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(2017) conducted chick chorioallantoic membrane (CAM), endothelial tube formation and enzyme-linked immunosorbent assays

Until such evidence emerges, clinical decision-making must rely on extrapolation from general population data, pharmacological principles, and individualized risk-benefit assessment