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Homeostatic bone requires a balance of bone formation and resorption
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References 6B3J: Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D
These approaches constrain confounding and selection bias during the design phase rather than relying on post hoc statistical corrections