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Candidates typically have weight-related health concerns or difficulty controlling appetite
Semaglutide has robust clinical trial data demonstrating lower average weight loss and higher rates of significant weight loss, while AOD-9604 results are limited and not sufficient for treatment of major obesity
A landmark study published in Nature Medicine (Koeth et al., 2013) demonstrated that gut bacteria metabolise L-carnitine into trimethylamine N-oxide (TMAO), a compound associated with atherosclerosis in animal and observational human studies
doi: 10.1016/j.bcmd.2007.09.001
Since semaglutide already impairs the normal B12 absorption pathway, using a form that requires fewer metabolic steps to become active reduces the total burden on an already stressed system
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