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In patients with PD, ECs in the basal ganglia undergo degeneration, accompanied by a reduction in the expression of TJs including occludin, and ZO-1 [221]

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In addition, acute central and peripheral administration of acyl-GIP increased c-Fos neuronal activity in hypothalamic feeding centres and decreased body weight and food intake [70]

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Most clients report feeling refreshed, more focused, and energised within hours, with cumulative benefits over time

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1 Many fertility clinics will ask about GLP-1 use during initial consultations

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