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Stereotaxic injections LepRb-Cre mice were anesthetized with isoflurane (1.52.0%, 1 L/minute in O 2 ) and placed in a stereotaxic frame (Kopf Instruments, Tujunga, CA)

Disease-associated changes in bile acid profiles and links to altered gut microbiota

Semaglutides (Ozempic and Wegovy) are a class of molecules known as GLP-1 (Glucagon-like peptide 1) receptor agonists that mimic a hormone, GLP-1, in the body to increase the secretion of insulin, lower glucagon, control sugar spikes, and suppress appetite, leading to weight loss

DAlessio, Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction