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**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A

At baseline, patients with MetS showed a lower antiplatelet response to aspirin and higher platelet reactivity

The use of peptides that have not been evaluated and approved by the FDA, or the use of FDA-approved peptides for purposes other than their specified indication, is known as 'off-label' use