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It binds to GHS-R1a on pituitary somatotrophs, activating the Gq-phospholipase C-IP3 signaling cascade to trigger GH granule exocytosis

Clinical data from both the STEP and SURMOUNT trials shows that GI side effects are concentrated during dose escalation and resolve for most participants within 4-8 weeks at any given dose level

Brian VanderBeek, an associate professor of ophthalmology at the Hospital of the University of Pennsylvania, in a commentary accompanying the study

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When a needle pricks a vein, theres always a chance that some bruising will occur around the site where the needle was inserted