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doi: 10.1038/nri3787 39 Fernandez-RuizRNiewoldTB

Gaffney RG, Merola JF

Bay-Richter C, Linderholm KR, Lim CK, Samuelsson M, Trskman-Bendz L, Guillemin GJ, et al

According to McGowan: Anyone with baseline reduced muscle mass should be cautious when starting a GLP-1 medication

For example, administration of metformin (1000 mg) via a nasoluminal catheter into the ileum, a region of the gut that is rich in L cells did not elicit any GLP-1 response over a 1 h period in patients with type 2 diabetes [8]