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AD is caused by oxidative stress and its products that damage DNA, lipids, proteins, and many macromolecules, aggravating the development of neurodegenerative diseases

In LPS/carbonyl cyanide 3-chlorophenylhydrazone (CCCP)-induced fever models in rats, catalpol undergoes deglycation in vivo , where its hemiacetal group covalently binds to Lys239 of UCP2 in the mitochondria of the liver via an -amine nucleophilic addition

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It is noteworthy that these potential pathogens are also detectable in healthy individuals, indicating that BRD development is more associated with disruption of host microbial balance than with simple pathogen invasion 103