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At the base-case drug price, treatment was cost-effective at $150,000/QALY threshold only if used for 7 years or less

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5 Two factors drive this gap: Early discontinuation: About 22 % of semaglutide users and 16% of tirzepatide users stopped treatment within the first year, and many more quit after the one-year mark

PYY 1875 is an agonist targeting the neuropeptide Y receptor 2 (Y2R)