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In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)

If a person is deficient due to insufficient B12, they may need to organize their diet to include more B12-rich foods or take an oral supplement

Targets 129 MorelloM.LandelV.LacassagneE.BarangerK.AnnweilerC.FeronF.et al (2018)

Subjects had to be over 15 years of age, present with soot in the mouth and expectoration (to indicate smoke exposure), and have altered neurological status

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