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Tirzepatide is currently the most potent weight-lowering drug approved

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Ensuring adequate protein intake, maintaining nutritional supplementation, and avoiding excessive caloric restriction during transitions can help minimize this risk

Diabetes, weight, dosage, insurance, and pharmacy were the most weighted features

This effect was achieved through the gutbone axis (promoting the growth of Bifidobacterium longum , repairing intestinal mucosal barrier, inhibiting pro-inflammatory cytokines, and restoring Treg/Th17 balance in bone tissue), helping to inactivate the osteoclasts