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For one, under the benchmarking methodology applicable to agreement periods beginning on January 1, 2025, and in subsequent years, in accordance with 425.652(a)(8)(ii), we adjust an ACO's historical benchmark based on the highest of three positive adjustments for which it is eligible, either the regional adjustment, prior savings adjustment, or HEBA

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it mediates the hypoxic induction of erythropoietin and coordinates erythropoietin and erythrocyte production with iron metabolism Peritubular renal interstitial fibroblast-like cells and pericytes synthesize erythropoietin in an oxygen-regulated and HIF-2-dependent manner

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[DOI] [PubMed] [Google Scholar] 121.Nickens KP, Patierno SR, Ceryak S

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