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Activation of TLR4/NF-B/PFKFB3 pathway in preeclampsia causes trophoblast cells to preferentially use glycolysis over mitochondrial oxidative phosphorylation, ultimately resulting in trophoblast ATP deficiency and increased apoptosis (102)

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The following framework supports interpretable laboratory comparison: GLP-1R signaling: Compare concentration-response relationships for cAMP, -arrestin recruitment, receptor internalization, trafficking, and selected downstream markers in a defined GLP-1R expression system

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Wang, C., Zheng, D., Xu, J., Lam, W., & Yew, D