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This dramatic evidence gap defines the current landscape and shapes how we should interpret both the promising preclinical data and the abundant anecdotal reports

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We followed up on two hits that exhibited the strongest GxE interactions, SLC25A19 and SLC25A32, which are transporters of two B family vitamin-derived cofactors, thiamine pyrophosphate (ThPP, or vitamin B 1 ) and folate species (vitamin B 9 ), respectively