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SLE patients were randomized to receive either placebo or NAC in one of three treatment arms of increasing doses: 600, 1,200, or 2,400 mg twice daily for 3 months

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Mitigated damage from oxidative stress will contribute to the normalization of expression of Ca 2+ cycling proteins and collagens, leading to the reversion of fibrosis and normalization of Ca 2+ cycling, which translates to the normalization of systolic and diastolic dysfunctions at the whole-heart level