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Acosta Group is not the only researcher currently digging into the effect of these weight loss drugs on dining out

Here, the combination with other drugs such as RAAS blockers, SGLT2 inhibitors, and mineralocorticoid receptor agonists, which have also displayed renoprotective effects, needs to be taken into account as well

Despite this, payers remain conflicted on whether pharmaceutical treatment for obesity should be covered

Regardless, despite concerns about the financial impact on the federal budget, 61% of adults believe Medicare should cover weight-loss prescriptions for overweight individuals

Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics