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Partial trisomy 21 is uncommon and presents with a spectrum of symptoms that depend on the extent of the partial duplication of chromosome 21 (Antonarakis et al., 2020)

The Na + /K + -ATPase dysfunction and subsequent calcium overload not only impair energy utilization but also further promote mitochondrial ROS production and mtDNA release, which may serve as DAMPs to activate downstream immune pathways, forming a metabolic-immune cross-talk at the cellular level

Antioxidant status and lipid peroxidation in type II diabetes mellitus

Adv Immunol