glutathione reductase antioxidant Frontiers Glutathione Reductase - an overview

Because the mitochondrial leader peptide is cleaved off after import into mitochondria, c-GPx4 and m-GPx4 cannot be differentiated on the basis of their primary structure

Supports intracellular glutathione levels critical for antioxidant defense and helps to neutralize free radicals and support phase I and II detoxification

The thiolate cysteine sulphur then reacts with any reactive electrophile, which is able to dock in its own turn to the appropriate site of the enzyme

Aslam B, Asghar R, Muzammil S, Shafique M, Siddique AB, Khurshid M, et al

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