It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction (Tafti et al., 2024)
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Patients who are diagnosed or are suspected of having MCAS should always avoid known and possible triggers
Pathological studies in degenerating neurons have demonstrated that S-nitrosylation of Drp1 specifically mediates aberrant mitochondrial recruitment, thereby triggering cascade activation of PINK1/PARKIN pathway-mediated mitophagy (Li et al., 2019)