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RNK06395 degraded the ERK5 protein in several cell lines, including Huh-7 (Dmax of 71.3% with a DC 50 of 50.98 nM), MOLP-8 (Dmax of 84.7% with a DC 50 of 24.54 nM), and A427 (Dmax of 55.9% with a DC 50 of 186.8) (Fig

The authors concluded by advising dermatologists to keep alert of ocular symptoms and signs in psoriasis patients, provide relevant patient education and be able to collaborate with eye doctors when needed to provide prompt diagnosis and appropriate therapy for patients with ocular symptoms and signs to prevent irreversible sequelae. This article was developed by the editorial staff in conjunction with experts in the field

Clin Genet 2005

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities