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Furthermore, GPx1 variants Pro198Leu and C594T, which result in decreased enzymatic activity, were associated with increased risk of MASLD onset (Zhang et al

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7.1%), decreased appetite (13.5%, 14.5% vs

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The analysis found that GLP-1RAs increased the risk of cholelithiasis and likely increased the risk of GERD, though the absolute risk increases were small (2 extra cholelithiasis cases and 4 extra GERD cases per 1,000 treated patients)