Functional Characterisation of a SNP in the ABCC11 Allele Effects on Axillary Skin Metabolism, Odour Generation and Associated Behaviours. Journal of Dermatological Science, vol
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Gene expression profiling studies have reported that GHK-Cu exposure modulates several genes in human cell preparations, with published analysis of the Broad Institute Connectivity Map gene-expression datasets characterising GHK as modulating the expression of many genes and presenting these transcriptome-wide changes as a basis for the compounds range of documented cellular activities [3], making Copper Tripeptide-1 a compound of interest beyond conventional wound biology research
The lack of consistent changes in expression of Class I alleles in human or murine PCa cells suggests that the Class I upregulation and consequent CD8-dependent immune response reported in IGF-depleted or inhibited tumors 13,19 may be due not to reduced expression of MHC -chains, but rather to disruption of peptide transport and processing, and downregulation of invariant Class I component 2M
