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Specifically, IL-1 is constitutively produced and retained in keratinocytes, but in response to several stimuli, IL-1 is released, which is essentially a primary event of inflammation

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Muka T, Nano J, Voortman T, Braun KVE, Ligthart S, Stranges S, et al

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They think the FDA is just too slow in evaluating them, so they want to have them today versus five years or 10 years from now