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The antioxidant action of DTPA is derived from its ability to chelate Fe 3+ and thus prevent its reaction with superoxide and hydrogen peroxide, leading to formation of hydroxyl radicals (i.e., preventing HaberWeiss and Fentons reactions) ( 3+ DTPA is slowly reduced by superoxide, which results in the production of fewer hydroxyl radicals (Rahhal and Richter, 1988)

doi: 10.1016/bs.vh.2016.04.005

Several malignancies have been associated with alemtuzumab use in RRMS, including stage 1 thyroid papillary carcinoma with onset 1041 months from the last infusion, basal cell carcinoma, breast cancer, melanoma, non-EBV-associated Burkitt' s lymphoma, and Castleman disease

Clinical studies are primarily investigating Cagrilintide + GLP-1 agonists (like semaglutide)

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