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Mice were maintained on 12-h light/12-h dark cycles under 1823 C ambient temperature with 4060% humidity in an AAALACaccredited animal facility

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This N-terminal extracellular domain is connected to a core domain of the receptor consisting of seven transmembrane -helices interconnected by three extracellular loops (ECL 13) and three intracellular loops (ICL 13)

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