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IV use at appropriate infusion rates has not shown the same risk profile, but medical history review is standard Individuals with a known sensitivity to sulfur-containing compounds should inform their provider High-dose IV glutathione for cosmetic skin lightening, particularly in unregulated settings, has been associated with adverse events including anaphylaxis and reports of hepatotoxicity

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Clinical images taken after 3 weeks of treatment with intradermally injected diluted botulinum toxin demonstrated a marked reduction in erythema and edema , along with decreased inflammatory lesions and less conspicuous pores