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We typically increase the dose slowly over several weeks or months based on your tolerance and response
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This first-pass mechanism of periportal toxicity for selected compounds, including hepatotoxicants that primarily affect centrilobular hepatocytes, could result from deficient cytoprotective capacity secondary to depletion of phase II conjugating enzymes in addition to being a consequence of a higher exposure gradient to these upstream hepatocytes
Pigment Cell Melanoma Res (2013) 26(4):51826
Plan for side effects: Each dose increase can cause temporary GI symptoms
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