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Cai Q, Davis ML, Sheng ZH

The total number of proteins that bind calcium is beyond the scope of this discussion but several important examples of intracellular Ca 2+ -binding proteins include the calmodulins, calcineurins, calbindins, and troponins, whereas important extracellular Ca 2+ -binding proteins include the coagulation factors [II (prothrombin), VII, IX, X, protein C, protein S] and the cell-cell communication/adhesion proteins of the cadherin family

Necrotizing enterocolitis in neonates receiving octreotide for the management of congenital hyperinsulinism

Glutamate is converted to -KG both via GLUD1, generating glutamate-derived nitrogen as ammonia, and via aminotransferases, which transfer nitrogen from glutamate to -KG to produce other NEAAs

Apart from differential compartmentation, one possibility is that this array of enzymes guarantees robust redox homeostasis, even at the expense of redundancy, consistent with loss-of-function studies for APX and PRX isoforms in the chloroplast (Awad et al