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The former mainly include sulfonylureas, glinides, dipeptidyl peptidase-IV inhibitors (DPP-4i), and glucagon-like peptide-1 receptor agonists (GLP-1 RA), and the latter mainly include biguanides, thiazolidinediones (TZDs), -glucosidase inhibitors, and sodium-glucose cotransport-2 inhibitors (SGLT-2i)

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