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BPC-157 activates the VEGFR2-Akt-eNOS pathway, increasing blood vessel formation by 129% to 152% in damaged tissues according to preclinical studies

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2019;29(13):4540-4552.e8

Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Attia et al., 2023)