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Effect of berberine on islet cells of db/db mice We used H&E staining method to observe the shape of mouse islets (Figure 2A)

Foreseeability Eli Lilly should have anticipated gastroparesis risk because: The same mechanism (slowed gastric emptying) was known from GLP-1 drugs Tirzepatides dual action might amplify this effect Clinical trial data should have been scrutinized for GI complications 2

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