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doi: 10.1016/S0021-9258(18)34893-2 77 LiebermanMEMaurerRAGorskiJ

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Reduced Quantal Size : Under repeated amphetamine exposure, the combination of vesicular NE displacement (via proton gradient collapse) and VMAT2 blockade prevents newly recycled or recruited vesicles from being effectively refilled with NE (Sulzer et al, 1995

-KG deficiency blocks AMPK translation As an energy sensor, AMPK inhibits fatty acid synthesis and promotes FAO and mitochondrial metabolism to supply malate and isocitrate for NADPH homeostasis 26