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Physiology of incretins in health and disease

As you eat smaller portions and consume different foods, the bacterial populations in your colon adapt, and some species produce more sulfur compounds as a metabolic byproduct

Indeed, GLUTag cells express the IL-6 receptor, and IL-6 treatment increases GLP-1 secretion in a dose-dependent manner, where acute IL-6 treatment increases GLP-1 exocytosis in a JAK2-STAT3-dependent manner, and chronic IL-6 treatment increases GLP-1 content and glucose uptake in a sodium glucose transporter 1-dependent manner in the L cell (Ellingsgaard et al., 2011)

The contrast is stark

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