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10.1074/JBC.RA119.009591 [DOI] [PMC free article] [PubMed] [Google Scholar] Lu C, Wei Z, Jiang N et al (2022) Soy isoflavones protects against cognitive deficits induced by chronic sleep deprivation via alleviating oxidative stress and suppressing neuroinflammation

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If you recently titrated up to a higher dose and your constipation dramatically worsened, that dose increase is likely the primary driver

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Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4R-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice