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Spent entire 17 year career in surgery with experience in Cardiovascular and Thoracic surgery, Neurosurgery, and Orthopedic Trauma surgery

* Correspondence: Fang Zeng, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The calcium-binding affinity of S100 proteins is low in the absence of target proteins, but the affinity is significantly increased by several orders of magnitude in the presence of specific target proteins ( Figure 1 The 3D structures of S100 protein family have been resolved in three different states: Ca 2+ -free apo state, bound to Ca 2+ and bound to its target protein ( Because of multiple functions of the S100 proteins, many diseases, including psoriasis, are associated with altered expression levels of S100 proteins

However, these power plants are sensitive to oxidative stress

This approach allows for the creation of "all-in-one" high-potency treatments that address multiple skin concerns simultaneously without the risk of ingredient incompatibility in the bulk phase